Signals That Prompt Hair Growth Discovered, May Pave Way For Baldness Treatment
Stem cells still exist in the follicle roots of men with male pattern baldness, the researchers explain. However, they have lost the ability to trigger hair to re-grow. Even though scientist have known that these stem cells within the follicle need signals from somewhere within the skin to start growing hair, they were not sure exactly where the signals came from.
Horsley and team noticed that a layer of fat in the scalp shrinks when hair dies - this layer comprises most of the skin's thickness. When hair starts to grow, adipogenesis occurs - the layer of fat expands.
For hair regeneration to occur in mice, adipose precursor cells were needed, the scientists found. Adipose precursor cells are types of stem cells involved in creating new fat cells. These cells were also found to produce PDGF (platelet derived growth factors), types of molecules needed to
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